From another forum:

Im finding that (as i have every ability except 1) that a durability setup yields more total quality than a quality build.

This is because of diminishing returns on the quality gains, if you notice a synth starts and you will get 50+ quality a hit, but as the synth goes on this goes down to ~10 this means you have hit the the higher part of the quality gains.

I find using quality abilitys just allows hitting of the quality cap faster compared to durability which allows a lot more hits.

Byregots Blessing
Masters Mend
Manipulation/Meticulous Mind
Comfort Zone
Greater Calling x 3 rapid Finishes the synth


Thoughts? O.o

I am experiencing the same thing actually. I don't have all the abilities yet, but some of the "get more quality" abilities seem a tad unerwhelming. I need more tests to confirm though.

I spam Quality abilities to 40%-50%, then use By the Book and Piece by Piece to finish it off. 250-300 quality usually and almost no chance of failure.